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Pharmacokineticpharmacodynamic modeling in healthy volunteers demonstrated that the peptide is rapidly absorbed , producing a measurable increase in GH concentrations shortly after administration without significantly altering levels of other hormones such as cortisol or prolactin

Tesamorelin binds to GHRH receptors on somatotroph cells in the anterior pituitary, which triggers a cascade involving cyclic AMP that stimulates both the production and release of endogenous growth hormone